cftr inh172 Search Results


cftr inh172  (MedChemExpress)
94
MedChemExpress cftr inh172
Following overnight incubation in S-VX-121 ( A; 1 μM) or R-VX-121 ( B; 1 μM), forskolin (10 μM) and VX-770 (1 μM) induced an increase in I Cl that was inhibited by CFTR <t>inh172</t> (3 μM). C. Average responses to forskolin + VX-770 for experiments in A and B. DMSO (0.1%) was used as a control. D. Immunoblot of CFTR showing correction of F508del CFTR by S-VX-121, but not R-VX-121. E. Average results for 3 experiments. F. Cl − currents in response to forskolin following overnight incubation in S-VX-121 (1 μM; blue trace) or S-VX-121 (1 μM) plus R-VX-121 (3 μM) (red trace). G. Concentration-response relationship for inhibition of S-VX-121-induced correction of I Cl by R-VX-121. The data were fit to the Hill equation with an apparent IC 50 of 3.5 μM. H. Cl − currents in response to forskolin following overnight incubation in VX-445 (1 μM; blue trace) or VX-445 (1 μM) plus R-VX-121 (6 μM) (red trace). I. Average response to forskolin for the experiments shown in H (n=23). J, K, L. F508del CFTR was corrected with VX-445 (1 μM) plus VX-661 (3 μM). Forskolin was used to stimulate I Cl and the effect of VX-770 (1 μM; J ), S-VX-121 (10 μM) followed by VX-770 ( K ) or R-VX-121 (10 μM) followed by VX-770 ( L ) determined. CFTR inh172 (3 μM) was used to confirm I Cl was due to CFTR. M. Chemical structures of VX-770, S-VX-121 and R-VX-121. #, P<0.01.
Cftr Inh172, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cftr+inh172/CFTR(inh)-172/pmc12621279-90-9-15
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cftr(inh)-172  (TargetMol)
N/A
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cftr inh 172  (Adooq Bioscience LLC)
90
Adooq Bioscience LLC cftr inh 172
Following overnight incubation in S-VX-121 ( A; 1 μM) or R-VX-121 ( B; 1 μM), forskolin (10 μM) and VX-770 (1 μM) induced an increase in I Cl that was inhibited by CFTR <t>inh172</t> (3 μM). C. Average responses to forskolin + VX-770 for experiments in A and B. DMSO (0.1%) was used as a control. D. Immunoblot of CFTR showing correction of F508del CFTR by S-VX-121, but not R-VX-121. E. Average results for 3 experiments. F. Cl − currents in response to forskolin following overnight incubation in S-VX-121 (1 μM; blue trace) or S-VX-121 (1 μM) plus R-VX-121 (3 μM) (red trace). G. Concentration-response relationship for inhibition of S-VX-121-induced correction of I Cl by R-VX-121. The data were fit to the Hill equation with an apparent IC 50 of 3.5 μM. H. Cl − currents in response to forskolin following overnight incubation in VX-445 (1 μM; blue trace) or VX-445 (1 μM) plus R-VX-121 (6 μM) (red trace). I. Average response to forskolin for the experiments shown in H (n=23). J, K, L. F508del CFTR was corrected with VX-445 (1 μM) plus VX-661 (3 μM). Forskolin was used to stimulate I Cl and the effect of VX-770 (1 μM; J ), S-VX-121 (10 μM) followed by VX-770 ( K ) or R-VX-121 (10 μM) followed by VX-770 ( L ) determined. CFTR inh172 (3 μM) was used to confirm I Cl was due to CFTR. M. Chemical structures of VX-770, S-VX-121 and R-VX-121. #, P<0.01.
Cftr Inh 172, supplied by Adooq Bioscience LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cftr+inh172/cftr+inh+172/pmc11647873-54-17-22
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cftr inh 172  (Enzo Biochem)
90
Enzo Biochem cftr inh 172
Following overnight incubation in S-VX-121 ( A; 1 μM) or R-VX-121 ( B; 1 μM), forskolin (10 μM) and VX-770 (1 μM) induced an increase in I Cl that was inhibited by CFTR <t>inh172</t> (3 μM). C. Average responses to forskolin + VX-770 for experiments in A and B. DMSO (0.1%) was used as a control. D. Immunoblot of CFTR showing correction of F508del CFTR by S-VX-121, but not R-VX-121. E. Average results for 3 experiments. F. Cl − currents in response to forskolin following overnight incubation in S-VX-121 (1 μM; blue trace) or S-VX-121 (1 μM) plus R-VX-121 (3 μM) (red trace). G. Concentration-response relationship for inhibition of S-VX-121-induced correction of I Cl by R-VX-121. The data were fit to the Hill equation with an apparent IC 50 of 3.5 μM. H. Cl − currents in response to forskolin following overnight incubation in VX-445 (1 μM; blue trace) or VX-445 (1 μM) plus R-VX-121 (6 μM) (red trace). I. Average response to forskolin for the experiments shown in H (n=23). J, K, L. F508del CFTR was corrected with VX-445 (1 μM) plus VX-661 (3 μM). Forskolin was used to stimulate I Cl and the effect of VX-770 (1 μM; J ), S-VX-121 (10 μM) followed by VX-770 ( K ) or R-VX-121 (10 μM) followed by VX-770 ( L ) determined. CFTR inh172 (3 μM) was used to confirm I Cl was due to CFTR. M. Chemical structures of VX-770, S-VX-121 and R-VX-121. #, P<0.01.
Cftr Inh 172, supplied by Enzo Biochem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cftr+inh172/cftr+inh+172/pmc03362005-245-2-8
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cftr(inh)-172  (FUJIFILM)
90
FUJIFILM cftr(inh)-172
Following overnight incubation in S-VX-121 ( A; 1 μM) or R-VX-121 ( B; 1 μM), forskolin (10 μM) and VX-770 (1 μM) induced an increase in I Cl that was inhibited by CFTR <t>inh172</t> (3 μM). C. Average responses to forskolin + VX-770 for experiments in A and B. DMSO (0.1%) was used as a control. D. Immunoblot of CFTR showing correction of F508del CFTR by S-VX-121, but not R-VX-121. E. Average results for 3 experiments. F. Cl − currents in response to forskolin following overnight incubation in S-VX-121 (1 μM; blue trace) or S-VX-121 (1 μM) plus R-VX-121 (3 μM) (red trace). G. Concentration-response relationship for inhibition of S-VX-121-induced correction of I Cl by R-VX-121. The data were fit to the Hill equation with an apparent IC 50 of 3.5 μM. H. Cl − currents in response to forskolin following overnight incubation in VX-445 (1 μM; blue trace) or VX-445 (1 μM) plus R-VX-121 (6 μM) (red trace). I. Average response to forskolin for the experiments shown in H (n=23). J, K, L. F508del CFTR was corrected with VX-445 (1 μM) plus VX-661 (3 μM). Forskolin was used to stimulate I Cl and the effect of VX-770 (1 μM; J ), S-VX-121 (10 μM) followed by VX-770 ( K ) or R-VX-121 (10 μM) followed by VX-770 ( L ) determined. CFTR inh172 (3 μM) was used to confirm I Cl was due to CFTR. M. Chemical structures of VX-770, S-VX-121 and R-VX-121. #, P<0.01.
Cftr(inh) 172, supplied by FUJIFILM, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cftr+inh172/cftr+inh++172/pm24713141-109-27-31
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cftr(inh)-172  (Aladdin Scientific Corporation)
N/A
Product Description：CFTRinh-172 (CFTR inhibitor 172) is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters.
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Following overnight incubation in S-VX-121 ( A; 1 μM) or R-VX-121 ( B; 1 μM), forskolin (10 μM) and VX-770 (1 μM) induced an increase in I Cl that was inhibited by CFTR inh172 (3 μM). C. Average responses to forskolin + VX-770 for experiments in A and B. DMSO (0.1%) was used as a control. D. Immunoblot of CFTR showing correction of F508del CFTR by S-VX-121, but not R-VX-121. E. Average results for 3 experiments. F. Cl − currents in response to forskolin following overnight incubation in S-VX-121 (1 μM; blue trace) or S-VX-121 (1 μM) plus R-VX-121 (3 μM) (red trace). G. Concentration-response relationship for inhibition of S-VX-121-induced correction of I Cl by R-VX-121. The data were fit to the Hill equation with an apparent IC 50 of 3.5 μM. H. Cl − currents in response to forskolin following overnight incubation in VX-445 (1 μM; blue trace) or VX-445 (1 μM) plus R-VX-121 (6 μM) (red trace). I. Average response to forskolin for the experiments shown in H (n=23). J, K, L. F508del CFTR was corrected with VX-445 (1 μM) plus VX-661 (3 μM). Forskolin was used to stimulate I Cl and the effect of VX-770 (1 μM; J ), S-VX-121 (10 μM) followed by VX-770 ( K ) or R-VX-121 (10 μM) followed by VX-770 ( L ) determined. CFTR inh172 (3 μM) was used to confirm I Cl was due to CFTR. M. Chemical structures of VX-770, S-VX-121 and R-VX-121. #, P<0.01.

Journal: American journal of physiology. Cell physiology

Article Title: (R)-vanzacaftor potentiates BK Ca channels in the absence of CFTR correction or potentiation

doi: 10.1152/ajpcell.00654.2025

Figure Lengend Snippet: Following overnight incubation in S-VX-121 ( A; 1 μM) or R-VX-121 ( B; 1 μM), forskolin (10 μM) and VX-770 (1 μM) induced an increase in I Cl that was inhibited by CFTR inh172 (3 μM). C. Average responses to forskolin + VX-770 for experiments in A and B. DMSO (0.1%) was used as a control. D. Immunoblot of CFTR showing correction of F508del CFTR by S-VX-121, but not R-VX-121. E. Average results for 3 experiments. F. Cl − currents in response to forskolin following overnight incubation in S-VX-121 (1 μM; blue trace) or S-VX-121 (1 μM) plus R-VX-121 (3 μM) (red trace). G. Concentration-response relationship for inhibition of S-VX-121-induced correction of I Cl by R-VX-121. The data were fit to the Hill equation with an apparent IC 50 of 3.5 μM. H. Cl − currents in response to forskolin following overnight incubation in VX-445 (1 μM; blue trace) or VX-445 (1 μM) plus R-VX-121 (6 μM) (red trace). I. Average response to forskolin for the experiments shown in H (n=23). J, K, L. F508del CFTR was corrected with VX-445 (1 μM) plus VX-661 (3 μM). Forskolin was used to stimulate I Cl and the effect of VX-770 (1 μM; J ), S-VX-121 (10 μM) followed by VX-770 ( K ) or R-VX-121 (10 μM) followed by VX-770 ( L ) determined. CFTR inh172 (3 μM) was used to confirm I Cl was due to CFTR. M. Chemical structures of VX-770, S-VX-121 and R-VX-121. #, P<0.01.

Article Snippet: Paxilline (HY-N6778), VX-445 (HY-111772), S-VX-121 (HY-145603), R-VX-121 (HY-145603A) and CFTR inh172 (HY-16671) were obtained from MedChemExpress.

Techniques: Incubation, Control, Western Blot, Concentration Assay, Inhibition

A. Concentration-dependent vasodilation of mesenteric artery by R-VX-121 from a male mouse. B. Average responses in male mice to S- (blue line, n=7) and R- (red line, n=7) VX-121. C and D . Average responses in male mice to R-VX-121 ( C ) and S-VX-121 ( D ) under control conditions (solid lines) and in the presence of 10 μM paxilline (Pax; dashed lines). Paxilline inhibited the response to both R- and S-VX-121 (n=8 for all conditions, P<0.01). E. Average responses in female mice to S- (blue line, n=7) and R- (red line, n=7) VX-121. F and G. Average responses in male mice to S-VX-121 ( F ) and R-VX-121 ( G ) under control conditions (solid lines) and in the presence of 3 μM CFTR inh172 (dashed lines). CFTR inh172 had no effect (n=8 for all conditions).

Journal: American journal of physiology. Cell physiology

Article Title: (R)-vanzacaftor potentiates BK Ca channels in the absence of CFTR correction or potentiation

doi: 10.1152/ajpcell.00654.2025

Figure Lengend Snippet: A. Concentration-dependent vasodilation of mesenteric artery by R-VX-121 from a male mouse. B. Average responses in male mice to S- (blue line, n=7) and R- (red line, n=7) VX-121. C and D . Average responses in male mice to R-VX-121 ( C ) and S-VX-121 ( D ) under control conditions (solid lines) and in the presence of 10 μM paxilline (Pax; dashed lines). Paxilline inhibited the response to both R- and S-VX-121 (n=8 for all conditions, P<0.01). E. Average responses in female mice to S- (blue line, n=7) and R- (red line, n=7) VX-121. F and G. Average responses in male mice to S-VX-121 ( F ) and R-VX-121 ( G ) under control conditions (solid lines) and in the presence of 3 μM CFTR inh172 (dashed lines). CFTR inh172 had no effect (n=8 for all conditions).

Article Snippet: Paxilline (HY-N6778), VX-445 (HY-111772), S-VX-121 (HY-145603), R-VX-121 (HY-145603A) and CFTR inh172 (HY-16671) were obtained from MedChemExpress.

Techniques: Concentration Assay, Control